Key enzyme identified for unique mode of malaria parasite replication

first_imgResearchers have identified an enzyme that plays a key role in malaria parasite replication in the human bloodstream. The Harvard T.H. Chan School of Public Health scientists say that developing drugs that target the enzyme could be a potential approach in efforts to treat and prevent the spread of the deadly disease.The study was published online February 17, 2017 in Nature Microbiology. Markus Ganter, research fellow in the Department of Immunology and Infectious Diseases, was the study’s lead author; senior author was Manoj Duraisingh, John LaPorte Given Professor of Immunology and Infectious Diseases.People can become infected with malaria—which kills roughly 500,000 people every year—when bitten by mosquitoes carrying the malaria parasite, Plasmodium falciparum. Until now, the molecular mechanisms behind the parasite’s replication in the bloodstream have been mysterious. The parasites have a “bizarre” form of replication within red blood cells called schizogony, Ganter explained. In normal replication, one cell would split into two. In the malaria parasite, within one cell, the nucleus replicates first into two, then continues to replicate unabatedly, until it reaches about 16 before splitting to form daughter parasites. Through this process, malaria parasites replicate quickly in the bloodstream and can kill rapidly.An enzyme known as P. falciparum CRK4 (PfCRK4) controls this replication and is active for most of the time the parasite is replicating within red blood cells, the researchers found. They also found that PfCRK4 plays a key role in the transmission of malaria from humans back to mosquitoes. Read Full Storylast_img read more

Governor Wolf Outlines Restore Pennsylvania’s Benefits for Boroughs

first_img June 11, 2019 Governor Wolf Outlines Restore Pennsylvania’s Benefits for Boroughs Press Release,  Restore Pennsylvania Hershey, PA – On the heels of the introduction of the Restore Pennsylvania legislation, today Governor Tom Wolf outlined how the proposal will help boroughs address critical infrastructure needs across Pennsylvania. Introduced with strong bipartisan support, the governor addressed hundreds of local leaders at the Pennsylvania State Association of Boroughs Annual Conference.“Over the last six months I’ve been traveling across Pennsylvania visiting communities with infrastructure investment needs. Many of these communities were boroughs in need of assistance with expanding broadband, removing blight, and cleaning up contaminants,” said Governor Wolf. “Infrastructure issues like this are why I’ve proposed Restore Pennsylvania to help communities of all sizes, including boroughs, modernize and move ahead, making Pennsylvania a leader in the 21st century economy.”Restore Pennsylvania was introduced in the legislature last week with a majority of the General Assembly supporting the historic legislation. House Bill 1585, sponsored by Rep. Jake Wheatley and Rep. Thomas Murt, has 99 cosponsors and Senate Bill 725, sponsored by Sen. John Yudichak and Sen. Tom Killion has 25 cosponsors. More than 60 stakeholders and municipal leaders are also endorsing the proposal.Last week, the governor released a series of white papers detailing the investments Restore Pennsylvania would make, helping local communities prevent flooding, eliminate blight, expand broadband, and address other critical infrastructure needs.Storm Preparedness and Disaster RecoveryRestore Pennsylvania will provide funding to help towns and cities prepare for flooding and severe weather, upgrade flood walls and levees, replace high-hazard dams, and conduct stream restoration and maintenance.Providing High-Speed Internet AccessBroadband is essential to education, quality of life, and the economy. Lack of high-speed internet puts hundreds of thousands of Pennsylvanians at a disadvantage. Restore Pennsylvania will provide funding to completely bridge the digital divide in every community in Pennsylvania, making Pennsylvania a better place to work, do business, and live.Combatting BlightThere are an estimated 300,000 blighted structures in rural and urban communities throughout Pennsylvania. Restore Pennsylvania will increase resources for addressing blight by providing financial resources at the local level to establish land banks and acquire and demolish blighted buildings in order to create new development opportunities or provide new green space.Contaminant Remediation and Brownfield CleanupMany communities face issues with harmful contaminants, such as lead and Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS). Abandoned industrial and commercial sites are also still waiting for cleanup to unlock their potential as commercial, residential, or industrial sites. Restore Pennsylvania will address contaminant remediation and help brownfield clean-up throughout the commonwealth.Green InfrastructureRestore Pennsylvania will provide significant new funding to enable new environmental projects and new recreational opportunities across the state, including infrastructure and maintenance in state parks, creation, and revitalization of new local parks, funding best management practices to improve local water quality, and funding for new hiking, biking, and ATV trail projects.Transportation Capital ProjectsRestore Pennsylvania will provide funding for local road and bridge upgrades, create new flexible funding options for businesses that need local infrastructure upgrades to enable development projects and multimodal and large-scale capital projects for transit.Downstream ManufacturingRestore Pennsylvania will provide funding for infrastructure that helps build manufacturing facilities and other downstream businesses for the natural gas produced in Pennsylvania.Business Development, and Energy InfrastructureRestore Pennsylvania will help businesses and individuals use more of Pennsylvania’s natural gas in their homes, creating jobs, lowering costs, and improving energy efficiency.Restore Pennsylvania will invest $4.5 billion over the next four years in significant, high-impact projects throughout the commonwealth to help catapult Pennsylvania ahead of every state in the country in terms of technology, development, and infrastructure. The plan is funded through the monetization of a commonsense severance tax. The existing impact fee will remain in place.The projects would be identified by local stakeholders and evaluated through a competitive process to ensure that high-priority, high-impact projects are funded and needs across Pennsylvania are met.center_img SHARE Email Facebook Twitterlast_img read more

UW hoping to burn Phoenix

first_imgUW senior guard Rae Lin D\’Alie is looking forward to the in-state rivalry game with UW-Green Bay.[/media-credit]Fresh off a down-to-the-wire 70-68 home victory over Cleveland State Sunday, the Wisconsin women’s basketball team (3-0) will look to protect its undefeated record Tuesday night when it hosts in-state rival — and fellow unbeaten team — UW-Green Bay (3-0).The Badgers can expect another tight contest from the Phoenix, who unsurprisingly were tabbed preseason favorites in the Horizon League, a conference they have won or shared the regular season title in for 11 consecutive years. For comparison, Cleveland State was picked to finish second in the Horizon League.Despite losing four starters from last year’s 29-4 squad, the Phoenix have a remarkable track record to validate the preseason expectations — particularly of note, the school hasn’t seen a losing campaign since 1977-78.“They have a tremendous tradition and reputation,” UW head coach Lisa Stone said. “They’re a very good team, whether they’re at home or on the road. … It doesn’t take motivation because this is an NCAA team we’re playing, and we’ve got to bring our best.”The game between in-state rivals marks the second of three games in Wisconsin’s quest to sweep its in-state rivals for the second straight year. The team defeated UW-Milwaukee last Thursday, 64-55, and faces Marquette in Milwaukee on Dec. 11.Because of last year’s sweep and Wisconsin’s status as the biggest school in the state, senior guard Rae Lin D’Alie said other Wisconsin schools always want to topple the Badgers.“[With] in-state games, you got to come to play because they’re coming to play,” D’Alie said. “People refer to it as the ‘Badger State,’ and everybody [from other schools] wants to prove it’s not the ‘Badger State,’ and we want to prove we are. … It’s fun because you get a lot of fans out here that want to see a good, interstate rivalry.”And although UWGB comes in undefeated and has won 20 plus games in 10 straight seasons, Wisconsin holds the all-time edge in the series, 19-6, including victories in the last two meetings, and four of the last five.Additionally, tomorrow’s game will be an early test of the Badgers conditioning as the team will take the court just over 48 hours after a grueling, come-from-behind win over CSU. In that game, the Badgers trailed by as much as 15 before prevailing in the final minutes.Junior forward Tara Steinbauer said the team doesn’t mind the schedule, however, which prepares the team for the grind of the Big Ten.Steinbauer, one of four Badgers averaging double figure scoring — along with junior guard Alyssa Karel, D’Alie and junior forward Lin Zastrow — added Sunday’s win symbolized one way in which this year’s team has improved over last.“We showed a lot of toughness in that second half,” she said. “I think the biggest thing we showed that’s been different from previous years is that we can change it around. A lot of times we would get in a slump, and it was kind of like we would stay in that slump, but I think we did a really good job of responding to what the coaches said at halftime.”The Badgers will need that resilience against a Phoenix group that is outscoring opponents by 14 points a game, outrebounding them by nearly six per game and, like Wisconsin, features a starting lineup with four players that average over 10 points per game.For one last measurement, the teams share one common opponent in the early nonconference season — North Dakota — which they both defeated by a sizable margin (UWGB by 18, Wisconsin by 25).But, regardless of how evenly matched the teams are on paper, Stone said with two Wisconsin teams you can always expect a dogfight.“Anytime, for an interstate rival you throw out the records, and you got to play because we’re going to get their best shot.”last_img read more

CAF CONFEDERATION CUP: Enyimba Holds Rayon Sports in Kigali

first_imgBy Duro IkhazuagbeNigeria’s lone team in continental campaign this season, Enyimba FC of Aba, moved a step closer to reaching the semi finals of the 2018 CAF Confederation Cup when the People’s Elephant yesterday secured a crucial goalless draw with Rayon Sports in Kigali, Rwanda.Enyimba defied the total home support for Rayon Sports at the Stade Nyamirambo in the Rwandan capital city to put one foot in the semis. Victory for Enyimba at the newly refurbished Aba Stadium on Sunday, September 23, will put the Abia State owned team close to also becoming the first Nigerian team to win the CAF Confederation Cup just the same way it ended the Champions league jinx.In Rwanda, goalkeeper Theophilus Afelokhai, who continues to bench Super Eagles star Ikechukwu Ezenwa, was outstanding for the People’s Elephant.Reports from Rwanda confirmed that the former Kano Pillars ‘keeper pulled off a big save after just 20 minutes of play to deny Gikundiro of scoring the game’s opening goal.He was again at his best in the 73rd and 75thminutes to deny Rayon Sports the edge they sought going into Sunday’s reverse fixture in Aba.Of course, Enyimba also had their chances to get on the scoreboard but both striker Mustapha Ibrahim and winger Wasiu Alalade threw away good chances. It was Alalade who pulled Enyimba into the quarter final with his crucial goal against CARA Brazzaville in the Group’s last game in Aba.Enyimba took control of the game in the second half and were let down again by their profligacy in front of goal.The duo of Ibrahim Mustapha and Sunday Adetunji wasted clear-cut chances in the 48th and 60th minutes respectively.In another quarter- final game, Raja Casablanca defeated their hosts, CARA Brazzaville 2-1.The overall winners of both games will come face-to-face in the semi-finals of Africa’s second-tier club competition.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegramlast_img read more

City League girls fail to get past first round

first_imgby Malik Vincent For New Pittsburgh Courier The top four teams in the City League qualified for the PIAA State Playoffs, for either a first round or play-in game. None of them were able to get past their first opponents to advance, with only Westinghouse being competitive.First round games:In Class AAAA, Allderdice was defeated by Mt. Lebanon, 70-22, on March 11 at Brashear. The Dragons were led by Janay Bottom’s 8 points. “I feel we could have represented ourselves better to Mt. Lebanon,” said coach Dave Walchesky. “We really took one to the chin.” Mt. Lebanon was led by Madison Cable with 18 points.Westinghouse fell to Indiana, 47-31, in AAA on March 12 behind Shanese Nelson’s team-best 9 points. “We just needed to be more mature,” Bulldogs coach Phyllis Jones said. “I think our kids hung in their well. To be able to get to the first round of state is an accomplishment.”Indiana was led by Leslie Stapleton’s 16 points.Play-in rounds: Brashear lost to Oakland Catholic, 71-15 on March 8. Eleven of Brashear’s 15 was scored by junior Nautica Buchannon. Mara Fitzgerald and Bobbi Baker each scored 12 to lead the Eagles of Oakland Catholic.New Castle romped past Perry 63-9, also on March 8. Marritta Gilcrease led Perry with four points, while New Castle featured four players in double figures led by LaShauna Brothers with 21 points.(Malik Vincent can be reached at [email protected]) NOWHERE TO GO—Westinghouse freshman point guard Kayla Key tries to find an opening against the Indiana defense. The Lady Bulldogs struggled against the Lady Indians and lost 47-31 in the first round of the PIAA playoffs. last_img read more

New Law Bans Smoking on Public Beaches

first_imgMartens, of Neptune, also believed a cultural change is underway. Fewer people are smoking and it’s for the better, he said.“You don’t see ashtrays in cars anymore, do you?” Martens questioned.Some people, though, think the law could be overreaching. That was Peter Lehmann’s opinion, a German citizen who was concluding a three-week tour of the East Coast at the Jersey Shore. He happened to be finishing a Seneca cigarette before paying the beach entrance fee.“It’s a bizarre thing,” said Lehmann. “We have seen all over the United States that it’s quite complicated.”“(Smokers) have to compromise all the time,” he added, “but to make it completely banned is too much.”This article was first published in the July 26-Aug. 2, 2018 print edition of The Two River Times. By Jay Cook | SEA BRIGHT – Melissa D’Anna was never a fan of smoking on the beach. And that was before she recently stepped on two lit cigarettes while giving surfing lessons in Long Branch.“It’s just a nuisance,” said D’Anna, the owner of Lucky Dog Surf Co. in downtown Sea Bright. “If you want to hurt yourself and your life, it’s your choice. But do it elsewhere.”D’Anna is just one of the many Two River-area residents who applauded a new state law signed by Gov. Phil Murphy last week that will ban smoking and vaping on all public beaches and parks across New Jersey. It’s set to go into effect in January 2019.Alongside other state officials in Long Branch July 20, Murphy said the law is designed to address public health issues and environmental concerns. “The Jersey Shore has always been one of the state’s, and indeed our nation’s, great natural treasures and a place for families,” said Murphy. “Today, we’re only strengthening our commitment to the Shore.”The bill is an extension of the New Jersey Smoke-Free Air Act of 2006 which prohibited smoking at any indoor public space or workplace. Smokers will no longer be allowed to light up on any municipal, county or state beach, park or forest.First-time offenders could be fined $250. A second offense may cost $500 and any subsequent time after that can cost $1,000.Municipalities and counties, however, can use local legislation to set up a designated smoking area not exceeding 15 percent of the beach. While there is some leeway designed in the law, it’s still a win for “fish and families,” said Cindy Zipf, executive director of Clean Ocean Action. Her organization conducts two beach sweeps annually and removed over 29,000 cigarette filters, 7,000 cigar tips, 1,100 lighters and 1,000 cigarette packs from nature just last year.“A lot of people just view their world as an ashtray,” Zipf told The Two River Times this week. “But no longer is the beach going to be one.”Some areas would be exempt from this legislation. The private beach clubs lining Ocean Avenue in Sea Bright wouldn’t have to adhere, said Zipf. It would be up to the individual club to put a ban in.“It would be interesting to see if this would be a way for them to choose to either take part or not,” Zipf said of the beach clubs. “This is a step in the right direction.” The same goes for national parks, like Gateway National Recreation Area where Sandy Hook is located. Guidelines dictated by the National Park Service only prohibit smoking within 25 feet of and inside any enclosed structure, as well as inside government-owned cars and boats.Some beachgoers who spent the afternoon in Sea Bright this week were receptive to the new legislation, like Doug Rice, 62, of Rumson.“No matter where you are, somebody’s going to be down-wind,” he said, before hopping back on his bicycle. “The other (bad) thing is the butts that go in the sand all the time.”Mel Martens, who was working a shift at Giglio’s Bait & Tackle, welcomed the ban.“Being a former smoker and knowing people that’ve smoked for 50 years, having a designated area would make sense to me,” he added.last_img read more

Dogs regain lead in Okanagan, Kootenay Final resumes Thursday

first_imgOsoyoos out shot the Grizz 43-29, including a wide 21-4 margin in the opening frame.Kyle Laslo out dueled a busy Tory Caldwell in the nets to register the win.Rebels back at home to host Riders in Game three ThursdayThe Castlegar Rebels play host to the Fernie Ghostriders in game three of the Kootenay Conference Final Thursday in the Sunflower City.The teams split the first two games of the series in Fernie. Game time is 7 p.m. at the Castlegar Complex. Mark Miller scored a power play goal with less than six minutes remaining in the game to spark the Osoyoos Coyotes to a 2-1 Kootenay International Junior Hockey League playoff victory over the Grizzlies Wednesday in Revelstoke.The win gives the Dogs a 2-1 lead in the Okanagan Conference best-of-seven series. Game four is Thursday in Revelstoke.Since being hit with eight goals in the opener, the Coyotes have tightened up the defensive end against the defending KIJHL champs, allowing three goals in two games.Taylor House also scored on the power play for Osoyoos giving the visitors a 1-0 lead after 40 minutes. Bruce Silvera tied the game, also on the power play, midway through the third.last_img read more

Mallard’s Source for Sports Team of the Week — CBT Youth Advisory Committee

first_imgThe Columbia Basin Trust rolled out the red carpet on its 2011 Youth Advisory Committee (YAC) recently in Golden. YAC members are motivated and involved youth age 15-29 who provide advice on youth-related grants and events at CBT. The YAC is an important means for CBT to engage with Basin youth and through their participation they are able to build their own skills as leaders said CBT director of Youth Initiatives Wayne Lundeberg. Staff and management at Mallard’s Source for Sports would like to add to the congratulations of the new YAC members with Team of the Week accolades. The YAC squad includes, left to right, Miranda de Groot (Cranbrook), Sierra Franklin (Canal Flats), Tessa Jackson (Nelson), Jane Rolandi (Cranbrook), Jaya Ducharme (Winlaw), Taryn Walker (Revelstoke) and Zeb Hansell (Fruitvale). Seated L-R: Zachary McClean (Golden), Blake Nicol (Nelson) and Kyler Perepolkin (South Slocan). For more information check out:http://thenelsondaily.com/megaphone-blast/six-new-members-join-cbt%E2%80%99s-youth-advisory-committeelast_img read more

Silver the colour of medal for Atom Leafs in Kimberley

first_imgThe Nelson Atom Leafs took their game on the road this past weekend, scoring a silver medal at a minor hockey tournament in Kimberley.The Atom Leafs dropped a 5-1 decision to Claresholm, Alta, in the final of the weekend event in the Bavarian City. Nelson cruised through the round robin scoring wins over Lethbridge Cougars 11-1, Cranbrook Crush 12-1 and Kimberley Nitros 8-1.The Leafs then faced a tough Castlegar Timberwolves in the semi final, edging the Sunflower City squad 5-4 in a thrilling battle.last_img read more

Site C capital cost estimate tabled at $8.335 billion

first_imgThe Site C capital cost estimate is tabled for $8.335 billion. It’s an increase over the $7.9 billion that was initially presented in 2010 and the increase comes as a result of “cost refresh” performed by B.C. Hydro this year to reflect “the advanced stage of project design and to prepare for a final investment decision by government.” The government has also established a reserve of $440 million to allow for cost overruns outside of B.C. Hydro’s control. The reserve which would cover things such as higher than expected inflation, and interest rates is subject to provincial Treasury Board approval.After the process was completed it was revealed that while has costs had escalated as a result of a longer environmental assessment process, enhancements to worker accommodation and larger diversion tunnels, the increases were offset from savings that came from lower than expected interest rates, design efficiencies, and a reduction in excavation requirements.The increase in the two figures reflects two key points: Costs associated with changing to an HST format to the provincial sales tales, and a construction start date of the summer of 2015.- Advertisement -A release from the Province states that if the capital cost estimate had not been updated to reflect the change from HST to PST that Hydro would have been forced to use funds from the project contingency budget. The Province felt it was for the best to increase the capital cost to account for the change to allow for full contingency.Construction on Site C was expected to have started in January of next year. Delaying construction until the summer will allow for more time to finish the permitting process. As a result the revised start date creates an increase in the construction period which in turn increases inflation and interest costs.last_img read more